Superbakteriy is dastardly villains medical world: Theyre hard to catch and kill, and they nullify helpless. This week, reports CNN
appearance of resistant Klebsiella pneumonia karbapenemam (CRKP), error were considered rare on the west coast in Los Angeles. For seven months in 2010 were 356 cases of CRKP, in the county health department - mostly in health care facilities like hospitals and nursing homes. CNNs chief medical correspondent Elizabeth Cohen said that this is the first time CRKP studied in Los Angeles and the District of incidence was unexpectedly high, according to a press release the Company Health Care Epidemiology of America. It is not known how many people died from this bacteria, but >> << found that previous outbreaks caused 35% mortality. Although the error was officially registered in 36 states, health professionals find it all in other states too, where reporting is not required. Thus, it was only a matter of time when the agent in the news on the West Coast, according to Dr. Robert Moellering, and a specialist in infectious diseases at Harvard. We asked Moellering some basic facts about CRKP and resistance to antibiotics. Q: What is CRKPP? : CRKP means karbapenem resistant Klebsiella pneumonia, which simply means that the bacteria - gram-negative bacteria that type that is associated with common organisms found in the gastrointestinal tract, like E. coli
- Karbapenemam this resistance, the type of antibiotic, which until recently was the antibiotic of last resort. Sometimes it still is, but not always. Previously, karbapenemy will work against bacteria such as Klebsiella pneumonia >> << that were resistant to any other type of antibiotics. Bacteria develop resistance almost as fast as Weve managed to develop new antibiotics. Q: How CRKPs drug resistance work? CRKP strains contain enzymes that destroy karbapenemy. A huge problem, however, is a company that [CRKP] holds. These together with other bacteria that are multidrug-resistant, and they contain genetic elements, DNA fragments that can be transferred to those of other bacteria. [It]
Klebsiella pneumonia can transfer genetic material to resist and have done so in the case of E. coli
hospital-associated infections. Gram-negative [bacteria] are more difficult to treat with antibiotics, even without drug-resistant because they have more structural problems. For example, they have two outer membranes, as antibiotics, to go through two separate barriers to reach these effectively. They also contain several pump that pumped toxic substances such as antibiotics. Q: When there are first CRKP? : Ive known about these organisms for 10 years or so. They first appeared in North Carolina, caused great concern in New York in Manhattan. Theyd already spread to California, they are nothing new in California. There just seems to increase the number of infections as well as heard about it [now]. Q: How can we avoid CRKP infection? : Stay away from hospitals and nursing homes! No, you can not do it. This is not what
you have to do as what hospitals should do. First, they must identify these organisms, send cultures reputable laboratories. And then the next step is to follow the CDCs standard methods of isolation: quarantine infected people to take precautions, contact wear gowns and gloves and hand washing practices. And by the way, talking about big, very well, university affiliated hospitals [these problems]. And you probably go out and get on the street? Chances are low. But the reason [these mistakes] are so terrible, because they spread and mutate strattera 10mg, so that now many of them [including CRKP] susceptible only to [antibiotic] kolistyn, which is very toxic and causes kidney damage. Some even get resistance to it, and then a few lines of defense. Thus, the mutation of bacteria in combination with a reduction in new drugs, you can see, we went to the collision. Q: Why Arent pharmaceutical companies allocation more resources on antibiotics? : Pharmaceutical companies largely withdrew from the business development of antibiotics. First of all, it is not easy, because all drugs have found simple. In addition, antibiotics actually treat patients - drug companies DONT always. Theyd, and develop statins and antidepressants, which you take for life, because they eventually sell more so Theres a big financial return for what you take for eight days, then never. In addition, there are large issues of regulation with the development of antibiotics in terms of obtaining FDA approval. They are taking steps to fix it, but they make it more difficult to do clinical research, they change the criteria for success at the crossing, they are not quite sure what their criteria. These are just some of the reasons why development has slowed, but very sad, because we desperately need new antibiotics. Q: Why be the epicenter of the hospital Superbug infections? : Hospitals contain patients and patients often seek infections with antibiotics. There is clearly some excessive use of antibiotics as well. You also have a group of patients who are more susceptible to infections, many of whom are immunocompromised, as they are undergoing chemotherapy or organ transplants - things that change their ability to fight infection. Another important factor displacement. Even in the best circumstances, some types of infection are required to pass. So that all hospitals can do right now - but just close your doors - it is best to try to follow the principles of infection control, as described in the CDC. If you do this and do it very well, the number of infected people will go down. I can not imagine there is not the main hospital, not trying to do this is though - it's not easy. Related links: CNNs Commissioner patient >> <<
No comments:
Post a Comment